Given the complexity of neuronal networks and that numerous areas of the brain involved in feeding express GLP-1Rs (198), it is plausible that many of the GLP-1R populations in the brain are involved, but may not be entirely essential, in mediating the effect of GLP-1RAs on energy intake
It also does not mean lifestyle alone can overcome genetics, age, biology, or established neurodegenerative disease
The pattern of results, particularly the amplification of benefit at higher weight loss thresholds, is consistent with the hypothesis that HRT restores a metabolic environment that makes GLP-1 therapy more effective: improving insulin sensitivity, preserving lean mass, reducing the inflammatory burden that blunts metabolic responsiveness, and supporting the mitochondrial function that underlies energy regulation
Additionally, its a good idea to check with your healthcare provider for tips or referrals to dietitians who can help you on your journey
While California, New Hampshire, Pennsylvania, and South Carolina stopped covering adult GLP-1 prescriptions for obesity on Jan